时间：2023-07-14

地点：电教楼国际报告厅

主持人：王力

主讲人：Wenfang Sun Prof. Wenfang Sun is the Robert Ramsay Chair in the Department of Chemistry and

Biochemistry at The University of Alabama (UA) since Nov. 2022. Prior to joining UA,

she was the James Meier Senior Professor and the Water F. and Verna Gehrts

Presidential Professor in the Department of Chemistry and Biochemistry at the North

Dakota State University (NDSU) (2001-2022). She has published 145 peer-reviewed

journal papers and 23 conference full papers. She has received numerous awards,

including the NSF CAREER Award (2005-2011), the James A. Meier Senior

Professorship (2016-2019), the NDSU Fred Waldron Award for Outstanding Research

(2012), the NDSU Walter F. and Verna Gehrts Professorship (2011-2013), the NDSU

Bison Ambassadors Apple Polisher Honoree (2009), the NDSU Featured Faculty (2006),

and the 2nd-Class Chinese Academy of Sciences Natural Science Award (2002).

内容简介：Transition-metal complexes with red to near-IR absorption are appealing potential

photosensitizers (PSs) for precision phototheranostics, especially those containing heavy

transition metals like Ru(II), Ir(III) and Os(II). This lecture would mainly focused on our

recent work on cationic and neutral Ir(III) complexes for photodynamic therapy (PDT).

We have demonstrated that a neutral Ir(III) complex tethered with a far-red absorbing

organic chromophore was encapsulated into polymer micelles and investigated as

bifunctional agents for 660-nm light-triggered synergetic PDT/photothermal therapy

(PTT) of breast cancer in vitro and in vivo. The micelle exhibited much enhanced

cellular uptake and higher tumor accumulation, demonstrating its great tumor selectivity.

This study demonstrated the potential of Ir(III) complexes to be developed into new farred/NIR PSs for cooperative cancer phototherapy.